Monotherapy antiepileptic drug trials in patients undergoing presurgical assessment: methodological problems and possibilities
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چکیده
منابع مشابه
Monotherapy antiepileptic drug trials in patients undergoing presurgical assessment: methodological problems and possibilities
It may fairly be claimed that up to the last decade no antiepileptic drug (AED) had undergone rigorous testing. Coatsworth I in a comprehensive review of AED assessment reported three controlled trials up to 1971, and Richens (1976) was able to identify some 17. Gram and coworkers found 51 by 1982, but the majority suffered gross methodological deficiencies. In the past decade the situation has...
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A number of clinical trials that test the efficacy and safety of the newer antiepileptic drugs (AEDs) have recently been concluded. Two dose-response trials in inpatients with refractory partial seizures and outpatients with newly diagnosed partial epilepsy established the efficacy of gabapentin as monotherapy. Lamotrigine was found to have efficacy similar to that of phenytoin and carbamazepin...
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Studies of new antiepileptic drugs (AED) present challenges unique to the treatment of seizures and epilepsy. Perhaps the most prominent of these challenges is the ethical concern of using an unproven medication alone in a study of patients with diagnosed epilepsy. As a result, the focus in the design of current methods of evaluating AED has been on patient safety. Given the constraints of the ...
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Antiepileptic drug (AED) monotherapy is the preferred initial management approach in epilepsy care, since most patients may be successfully managed with the first or second monotherapy utilized. This article reviews the rationale and evidence supporting preferential use of monotherapy when possible and guidelines for initiating and successfully employing AED monotherapy. Suggested approaches to...
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ژورنال
عنوان ژورنال: Seizure
سال: 1995
ISSN: 1059-1311
DOI: 10.1016/s1059-1311(95)80007-7